not explicitely, but jokes about “not letting women leave a party” are mentioned in a way that aren’t portrayed as rape but definitely don’t imply consent.
The room mate constantly puts herself in situations of distress or to make herself sound more desperate for the main characters friendship than anyone else.
The roommate is all but explicitly stated to be behaving the way she is (stalking, killing animals and people, etc) due to either having unmedicated bipolar disorder or schizophrenia. Upon finding out she's prescribed antipsychotics, the other characters get scared and treat her as dangerous. The word "ps*cho" is used at least once against the roommate.
Someone punches and hits themselves, and uses a box cutter to cut themselves on the stomach. The actual cutting is not shown, just the blade being pressed to the skin.
There are also several jokes about taking drunk girls up to your room and how getting girls home safe is "against everything we (a frat) stand for". These jokes are made by the "good guy".