There used to be a boy who could control Yo-kai with a mysterious watch. However, he became unable to see Yo-kai when he became an adult. With the boy's duties finished, the watch was buried away in space-time. Then 30 years later, quiet everyday life comes to an end as a fateful day beging with a comet drawing near. The terrible Yo-kai virus Onimaro infects people's malevolent intentions and spreads infinitely. The one chosen by the Yo-kai Watch is the one who can save humanity from its crisis. The bond between humans and Yo-kai may be recovered with the attainment of a new Yo-kai Watch.
The backstory of a dog yōkai, Komasan, mentions him getting crushed to death by a fallen statue when he was a living dog, turning him into a yōkai. The event itself is not shown.
Nothing happens to eyes. One character is an eyeball with a tiny body, arms and legs, but his appearance is brief and nothing bad happens to him. Another character has one of his eyes covered by his fringe hair, but we never see what's under the fringe.
A teenager is manipulated into believing that evil entities and their brainwashed victims are his friends, and that he is capable of single-handedly creating a better world if he seizes control of it.
No body dysmorphia is shown. A yōkai briefly mentions how being in his more inhuman form makes him want to revert to a humanoid form, but it is not depicted as a source of distress for him.
Every character is animated and played by a voice actor who is never shown on screen, so we cannot know whether or not they have the same disabilities as the characters.
No family members die. A character mentions a memento from his mother, but whether or not said mother is dead or simply not present in his life is never specified.
A yōkai appears as a three-headed snake-like monster, but he looks more like a dragon than a realistic snake, and he mostly stays in his humanoid form throughout the film.
Two of the characters live and work at a Shinto shrine, and characters based off of entities from Shinto, Buddhism and Hindu religions appear, but religion is never brought up or debated by the characters.
A character attempts to atone for his wrongdoings by risking his life in battle, but it is not depicted as a sacrifice. A group of characters sacrifice themselves to bring another one back from the dead.
A yōkai spits out a human he is holding in his mouth when hit with a magical blast. Another scene depicts a yōkai getting punched in the face, with visible saliva dripping out of his mouth due to the impact of the punch.
No one is shown to be homeless. It is unknown whether or not all yōkai shown have homes, but they never show distress about the topic or look for a place to live.
No one is stalked, but it is implied that one of the yōkai the main character had befriended follows her around in order to protect her, and she doesn't mind.