Jay's mom is an alcoholic and there's a lot of jokes about it whenever she shows up. There's also underage drinking in a few episodes like "The Head Push."
Not actually shown but in S4E6 a horse repeatedly kicks Coach Steve in the head before the horse and Steve get hit by a flaming meteor as the world ends
In the episode where Nick goes to Florida with Andrew, an alligator eats a child, which then shoots the alligator. It is graphic. & In Season 7 the Gratitoad dies.
S5E2 boy accidentally cuts his ball sack with scissors, boy gets his penis stuch in vaccum cleaner, girl gets a chicken egg stuck in her vagina (it doesn't break). everyone goes to hospital and turns out fine
By Nick's brother in "The Head Push," along with the f-slur. Also a joke in "Florida" when Coach Steve mistakes the phrase "fire retardant" for something else.
S1 Ep 4 Andrew has a sentimentally important pillow. He manages to save him but when Andrew and Nick escape from Jay's house the pillow tears.
S1 Ep 6 Andrew has a sentimentally important hat and loses it but find him.
The Christmas episode has a story about "Vader Johan" and it ends with the twins talking to the audience while the monster suddenly flashes behind them, if that counts.
S3E10 features a (child) character in the shower who pleasures herself with the shower head, though we don't see anything explicit. S4 has some shower scenes at camp, including child nudity.
S1
EP 2 when Jesse says she's on her period, Andrew instantly v *. 2 times. It happens in the toilet. Audio and visual
EP 4: Missy v * after eating sugar and being confused with Jesse, she v *. Audio and visual. A little later she came to the toilet. Only audio
Ep 6: Jay's pillow v * feathers. Audio and visual, later Andrew v * when (SPOILER) he sees Jesse's mother kissing a girl. Audio and visual
Ep 7: at the beginning Steve v * after being picked up by a teacher. Audio and visual. Also when Maurice gives Andrew a bag to breathe. Andrew g * after Maurice said what was in the bag. But he doesn't.
Ep 8: 2 scene. Jesse v * on Jay after drinking audio and visual liquor. Later at the end Nick (drunk) v * for a long time in Daniel's cap. Daniel is covered in v * until the end of the scene.
Ep 9: when Andrew and Missy run to the photo booth. Have seen on the pictures Missy v *. This is only visual and they are just pictures. See a bit of v * dripping from the photo booth when Andrew talks to Maurice.
The rest of the season is safe.
S2
Ep 1 Steve says he's lactose intolerant and throughout the episode he's going to eat yogurt, milshake ect ... and g * after that. The only v * and at the very end on the class photo and after that there are plenty of photos where he v * until the end of the episode. It seems to me that there is a little audio but there is mostly visual.
Ep 4 during Steve's song. A baby v *. Audio and visual
Ep 5 there is a flashback to Andrew's mother where she lives. Audio and visual but not too much visual
Ep 7. At the end of the trip when Nick and Andrew are in the trunk of the truck, Andrew mentions having v * in the trash can and saw a bit of v * dripping. It is only visual and have not seen it v *. Have briefly seen the result.
The rest of the season is safe but I want to point out that throughout the season from episode 5 to episode 10 when Steve talks about having sex he says "v * in a warm place"
S3
EP 2: when Nick says "I want to be allied to the cause of women" Maurice v *. Audio and visual.
EP 4: Nick's phone shows a video of someone eating pancakes and y * on his friends. Audio and visual
EP 10 Maurice v * d * ck when they see Lola having sex with her teacher. Audio and visual. Later some v * when he watches TV. Audio and visual
EP 11 Jay's brother in monster v * A blue liquid. Audio and visual.
the rest of the season is safe
S4
Ep 2: during the baseball scene. Milk v * on Nick, which makes v * Andrew, who will make v * his friends, who will remake v * Milk who will make v * the mosquito. Lasts at least 1 minute and audio and visual.
Ep 3 when Nick and Andrew are in the forest. A student v *. Audio and visual.
Ep 5: when Nick insults Connie she v * and says that when she cries she v *.
S5
Ep 4: towards the end, when Nick tells Jessie about Judd, Connie vomit
Ep 6: Missy has a hallucination of her killing Jessie and he v*
Ep 8: towards the beginning, Connie's puppet is drunk and she v*
S6:
Ep 3: towards the beginning there is a flashback of Jessie v* on Jay
Ep 4: around 14 minutes, when Devon is playing ball with the yogurt thief, the ball hits him in the stomach and he v*
A black person paints their face white and wears a wig in front of cops to hide their identity. In another episode Missy's dad is being consistently harrassed by airport security for being black
There is a scene where Jessi is taken to the “depression ward” it’s not a real psych ward it’s a fictional metaphor for depression. In season 4 there’s another scene where Jessi has her anxiety depicted as her being in a mental institution
In season 5 a couple different characters go to the hospital for minor injuries but you can only see them in the waiting room lobby after they've received treatment.
A girl has her first period and bleeds through her pants. There is a depiction of menstruation in the opening of every episode, where a uterus is flicked and blood drips out of it.
In one episode, Jay mentiones that he picks at his skin until it bleeds while in class and we very breifley see him do it. I used to do this in class all the time and it was very upsetting for me.
in the episode where andrew and nick go out with 7th graders, steve is shown as “lunch lady eve”. he is wearing a skirt, but it isn’t a main plot point or butt of a joke.
Less direct aphobia and more so excessive amatonormativity that is pretty uncomfortable (ex: the whole concept that a puberty monster that can't make their person horny is a failure)
Santa is genuinely real in the show but it's definitely not for kids to watch. Christmas episode, season 5: Santa has sex with mrs clause on screen. Elves have sex with each other on screen. Matthew tells his little sister Santa isn't real, Santa overhears this and beleives it, questioning reality. He stops delivering presents that Christmas Eve and gets drunk and passes out in the trash on the street.
S4E9 has a lot: Brief shot of blood on Nick's arm after he's cut with a knife, Mirror Missy's throat gets slit graphically, we also see Andrew disemboweled during the plane scene, Matthew's loved ones get sliced up. S4E10: Blood on a character's head during a fight scene (not explicit). S5E2 has gore in Missy's backne nightmare sequence and a LOT of blood when Jessi nicks her leg with a razor.