The only women being brutalized in RE4 are the female villagers that the player shoots, stabs, suplexes, blows up, sets on fire, flashbangs, and roundhouse kicks throughout the game.
Healing herbs are not explicitly treated as drugs, but the player character does need to take medication during the second half of the game in order to stave off an infection.
Huge but otherwise harmless spiders can be seen chillin' on setpeices. Luckily, they are rare and non hostile. A certain type of Plaga resembles a huge spider.
No, but in one room (area where you first encounter Regenerators) there are a pile of Regenerator bodies hanging from the ceiling. Regenerators are still very humanoid looking, so this might be a disturbing instance.
Mostly via optional death sequences. Dying to a certain enemy causes the player character's face to be melted off via acid, and the imagery is very unsettling.
The entire premise of the game is mind control. Multiple main characters are shown to be possessed by enemies and unable to control their own actions. The player character briefly assaults another friendly character while under the influence of said control.
No. It must be noted that later at the Island section of the game, there are enemies with stun batons that emit visual electricity which are used to electrocute Leon.
There is a conversation between Salazar and Leon about being part of a script and disappointing an audience, which seems odd if not intended to be a fourth wall break. The player is never addressed directly.
Not a minority, but the Spanish spoken by the Ganados seems to be a mix or mish mash of accents (Mexican, but no actual Castellan Spanish). Some Spanish used, isn't even correct Spanish.
No, but some enemies use dynamite as weapons. Leon can use and buy rocket launchers or explode explosive red barrels that create small explosions. At the end of the game, there's one huge explosion, but not nuclear in nature.