not sure if it’s necessarily abandoning but in the episode “pets peeved” the louds take in a stray dog. this upsets their other pets who carry out a plan to have the stray taken to an animal shelter
in one episode, i dont remember sorry if i rember i will update bobby is lightly stalked by the loud siblings (apart from lori) to see if he is cheating.
Animals are shown in situations which would cause them harm in real life (bird in small cylindrical cage, Hamster in a ball, lizards not in appropriate containers. There’s also references to animals getting hurt, such as when the frogs were rescued from getting dissected
the family locks luan (the prankster) in their basement before april fools day, she is later shown tied to a furniture dolly in the same episode as well
In "Potty Mouth", we learn that Lisa made science experiments on herself and got weird body changes. She hides them most of the time and she doesn't seem to mind.
In one episode, the girl Lola breaks an arm and a leg. Characters are also seen with limbs in casts in "A Fridge Too Far" (Luan), "House Flip" (Flip), and in all episodes that feature Paula, but the exact nature of the injuries is left unsaid. In "Picture Perfect", Lisa claims to have a broken bone somewhere on her body, but she seems fine.
In "Fandom Pains", the newly introduced character from the show revolving around the episode, "The Vampires of Melancholia", falls to their death from a cliff.
Maybe intentionally, maybe not, (probably intentionally given the show's creator), butna running joke with Lincoln (especially in season 1) is how he likes to read comics in his underwear. Probably not sexualization on its own, but ot can still be a little weird to watch, especially knowing what we do know about Chris Savino
I forget the name of the episode, but one episode revolved around using a toy to help the baby stop crying. The family regretted it due to having to listen to the toy all the time and threw it out, but when they tried to get it back, it ended up being destroyed. Should be noted that they did something to make up for it, however.
People sometimes talk about ghosts, but no ghosts feature in the series.
Update: With the exception of one episode, "Ghosted!", which does feature a ghost, but that's the only episode so far.
In one episode, Lana is shown vomiting on Rita's shirt in the beginning of an episode. This is a very brief scene but the vomit stays on her shirt until she changes it shortly after. This is one of the few episodes where the vomit is actually shown, though it's not very graphic.
In another episode, Lincoln convinces Lana to participate in a pageant to ride a carnival ride that would cause them to deliberately vomit. The vomit isn't shown in the actual scene (the end of the episode), but it is shown on a magazine of the ride. (also not very graphic.)
There are several other episodes where the characters may vomit, but it isn't displayed.
In "April Fools Rules", Lola implies that she wet her pants by saying she needs a new pair of underwear.
In "Schooled!", Lily poops her pants on purpose.
a running joke on the show is that the oldest sister lori farts and blames it on other things/people but farting in general happens a ton. if you don’t like toilet humor avoid the show
If you're uncomfortable with toilet humor, avoid this show. It's present in most (if not all) episodes, and some episodes focus pretty much entirely on bathroom jokes.
In the episode "Not a Loud", Lincoln's birth is mentioned, however, Rita does not seem to be in pain when she's in labor, Lincoln is clean when he's seen as a baby, and Rita's birth canal is not seen.
Lincoln occasionally disguises himself as a girl as part of a scheme and Clyde does in "Patching Things Up". In "Home of the Fave", Lynn Sr. wears dresses when playing with his daughters.
The Loud House features four LGBT characters: Luna who's bisexual, Sam who's either bisexual too or a lesbian, and Howard and Harold who are a gay couple. Neither of them die.
Not aphobia but in the episode "singled out", Lynn jr feels very lonely because she's the only ace/aro kid in her sports team. At the end, everyone turns out to be supportive.
there’s a ton of innuendos, but this is probably the most notable:
at the end of the episode “suite and sour”, after rita asks “think we should tell them why we really got kicked out?” it cuts to them in the hotel manager’s office, where he plays security footage of the parents sneaking into the hotel pool after hours, after they get in the pool offscreen you can see their swimsuits fly off and the water splashing in a kinda questionable way along with them laughing.
Lisa gives an equation which apparently disproves Santa, but then later she believes in him, but that's just their neighbour. Santa's existence is left ambiguous.