There is a scene at the end where a character willingly falls backwards off a cliff with the understanding that this could be a death sentence, so it can be read as such.
There IS a character that is very flirtatious and essentially naked (her breasts only being covered by hair, and the bottom barely covered by a skirt with a slit down the middle) but she's supposed to be a seductive demon that lures humans into hell, so I'm not sure if that counts
There is a mission where you are inside a flying whale demon. During two sections of this mission, you are going through its intestines and the walls are quite close together.
Most enemies produce Sand instead of blood when harmed. Overall actual blood/gore is rare, However the player and the rarely seen human enemies do bleed when injured. Dante gets stabbed several times, but since he can regenerate it doesn't seem to bother him.