For their first day on the job as the new protectors of Metro City, Megamind and Minion are selling off the gadgets from their evil lair. But when one seemingly harmless "button" unleashes the gigantic robot MEGA-MEGAmind, the duo will have to resort to their old tricks to restore order.
Main character comments on a "woman with a beautiful mustache" which causes said woman to gasp and cover her face. It's implied he was being genuine in finding it beautiful. (Even as a trans person I can't tell if this was done in bad taste; all I can say is the main character is previously established to not be concerned with gender norms, as he's an alien with an alien friend who likes pink frilly clothing but is otherwise depicted as masculine, and is shown supporting him.)
I don't know enough about this to feel super comfortable saying "no" without comment. There's one cartoony "water drip" noise near the end but I may be misunderstanding what audio cues would count for this, too.
Main character has a gun that "dehydrates" people, which kind of holds them in a state of frozen as a cube until they're rehydrated. A kid gets a hold of it and shoots his mom with it, turning her into a cube. It's meant in good fun.
The previously-mentioned enemy with a car-launcher does strike the main character's vehicle with a thrown car, but it bounces off and doesn't cause any noticeable damage.
Both main characters briefly get emotional, with the alien fish pretending to cry in his bowl as the other alien tells him to "pull himself together" as if possibly also saying that to himself. Both characters are immediately over it afterward.