A character smokes weed. A cop speculates that they might be on other drugs, but there is no evidence to support the allegation. Kids do unspecified drugs at a party where one of them is the dealer.
The protagonist's wife and the mother of his daughter died shortly before the beginning of the series and her funeral takes place in the first episode.
Two of the main characters are doctors and appear at their place of work. A character winds up in the hospital as the result of a stabbing. A character winds up in the hospital as the result of a seizure.
A character died of cancer before the events of the series, they later show them dead wearing a bandana on their head. Another character references their mother dying of cancer.
An LGBT person is the victim of a violent attack unrelated to their sexual orientation. They are hospitalized as the result of the attack but survive and do well for the rest of the series.